Journal de la nanomédecine et de la découverte biothérapeutique
Libre accès

Abstrait

Nano Pharmaceutical 2019: Critical role of membranes in nanoassembly of amyloid proteins- Yuri L Lyubchenko - University of Nebraska Medical Center, USA

Yuri.L.Lyubchenko

Statement of the Problem: The amyloid cascade hypothesis is currently considered as the main model for a vast number of neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s diseases. Numerous studies have shown that amyloidogenic proteins are capable of spontaneous assembly into aggregates, and eventually form fibrillar structures found in amyloid or amyloid