Cardiologie clinique et expérimentale
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Mutated LXR-A Gene within Blood Mononuclear Cells of CHD Patients: Significance of Serum Factors

Vivek P Dave, Deepak Kaul, Yashpaul Sharma, Rajasri Bhattacharya and Veena Dhawan

Several lines of evidence attest to the fact that the Liver X Receptor (LXR) -α dependent cross talk between lipid metabolism and inflammation may be of crucial importance in atherogenesis. The present study unambiguously revealed that the serum derived from coronary heart disease (CHD) patients does not possess any factor that had the inherent capacity to induce the observed LXR-α gene mutation in such patients. Surprisingly our experiments clearly indicated that vitamin D 3 could restore in part the functional activity of mutated LXR-α gene found in peripheral blood mononuclear cells of CHD patients. Our data also indicated that CHD patients contain significant low level of vitamin D 3 in their serum and this level is increased in such patients who are treated with atorvastatin. Based upon our findings, it’s not unlikely that restoration of serum vitamin D 3 level in such patients may be useful in arresting the progression of coronary atherosclerosis.