Médecine interne: libre accès

Médecine interne: libre accès
Libre accès

ISSN: 2165-8048


Morphogenesis of Metaplastic Changes in Gastroesophageal Reflux Disease

Kilessa AV and Filonenko TG

The aim of research is studying of morphogenesis of metaplastic changes in esophageal mucous and defining diagnostic and prognostic criteria in Barrett Esophagus (BE) disease.

Materials for histological and immunnohistochemical research were mucosal biopsies of distal esophagus received from 79 patients with clinical and endoscopic indicators of BE. Immunohistochemical research with using markers CK7 and CK20 is characterized by high sensitivity, specificity and accuracy allowing defining a phenotype of various types of metaplastic processes at endoscopically defined Barrett’s Esophagus.

Moderate CK 20 expression CK20, high level of Ki67 expression and P53 in mucous epithelium of cardial type testifies about transformation of cylindrical gastric epithelium in intestinal that confirms existence of a transition form of metaplasia in intestinal and can be a precursory diagnostic symptom of Barret’s Esophagus development.

Markers Ki67 and P53 are predictors of dysplastic and malignant cell’s regeneration due to gradual increase in its expression with the maximal values in biopsies of adenocarcinoma.