Médecine interne: libre accès
Libre accès

Abstrait

Mesenchymal Stem Cell: Therapeutic Intervention in Covid-19

Harshika Varshney, Rashi Srivastava, Kumari Swati, Ankur Sharma, Niraj Kumar Jha, Dhruv Kumar, Anand Prakash, Parma N, and Saurabh Kumar Jha

COVID-19, an ephialtes of mankind in the year 2020, is causing painful demise of many lives due to insufficient treatment and hence, creating a devastating history in making. This pandemic brought the world together and led many researches from different biomedical fields to find treatments and potent drugs; ought to help in managing the pandemic and future loss. However, till date no standard treatment has been discovered for COVID-19. Probably, preventing the severe respiratory infection cause by SARS-CoV-2 will give time for finding the most potent treatment for this disease. Easy and manageable methods are there for isolation of Mesenchymal Stem Cells (MSCs) which attracted the attention for number of therapeutic applications. Considering the present situation, treatment using Mesenchymal Stem Cells (MSCs) has been suggested as a satisfactory therapeutic approach. A noteworthy population of cells accumulates in the lungs after intravenous transplantation of MSCs which results in increasing the immunomodulatory effect that leads the protection of alveolar epithelial cells, refurbishment of the pulmonary microenvironment, and, prevent lung dysfunction and pulmonary fibrosis. There are several ongoing clinical trials based on MSCs for exploring out its efficiency in the treatment of COVID-19 patients. However, till date MSCs based treatment for COVID-19 is still not approved. This review involves the aspects of MSCs in the proposed treatment of COVID-19 and contains brief discussion on related ongoing clinical trials.