Journal des essais cliniques
Libre accès

Abstrait

Mechanism of Ozone Alleviation of Malignant Ascites in Hepatocellular Carcinoma through Inhibition of NETS

Feng Han, Jiayou Guo, Mingchen Mu, Ka Bian, Zhenting Cui, Qiong Duan, Jianxin Ma*, Lai Jin*, Wentao Liu*, Fanghong Chen*

Malignant ascites in hepatocellular carcinoma is usually a sign of advanced disease and poor prognosis and is also thought to be associated with chronic inflammation mediated by Neutrophil Extracellular Trap-networks (NETs). Whereas ozone, a strong oxidant, has significant antibacterial and anti-inflammatory effects, its effectiveness in treating malignant liver ascites is unclear. cOzone showed significant anti-peritoneal fluid production properties in H22 tumor-bearing mice, and ozone reduced peritoneal fluid production by activating AMPK and up-regulating SR-A phagocytosis Damage-Associated Molecular Patterns (DAMPs) to reduce the production of NETs. This suggests that ozone could be used as a new drug for the treatment of malignant ascites in hepatocellular carcinoma.