Journal d'ophtalmologie clinique et expérimentale
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Lens Thickness and Position of Primary Angle Closure Measured by Anterior Segment Optical Coherence Tomography

Li Mei, Wang Zhonghao, Mao Zhen, Zhong Yimin and Liu Xing

Purpose: To compare the lens’ thickness and position between symptomatic and asymptomatic primary angle closure (PAC) patients.
Methods: Sixty-six patients (66 eyes) with acute symptomatic PAC, 49 patients (49 eyes) with asymptomatic PAC and 32 normal controls (32 eyes) were enrolled at the Zhongshan Ophthalmic Center, Sun Yat-sen University. A-mode applanation ultrasonagraphy examination was performed to get axial length (AL). Anterior segment optical coherence tomography examination was performed to measure the anterior chamber depth (ACD), lens thickness (LT) and crystalline lens rise (CLR). The differences of these parameters among the three groups of symptomatic PAC, asymptomatic PAC and normal controls were compared.
Results: There was no significant difference of the mean age among the 3 groups (P=0.087). Compared with asymptomatic PAC eyes, symptomatic PAC eyes had significantly shallower ACD (2.02 ± 0.25 mm vs.1.84 ± 0.24 mm, P<0.001), thicker LT (5.04 ± 0.36 mm vs. 5.19 ± 0.38 mm, P=0.02), larger CLR (0.93 ± 0.21 mm vs. 1.09±0.26 mm, P< 0.01); and shorter AL (22.90 ± 0.76 mm vs. 22.26 ± 0.82 mm, P<0.001). Compared with symptomatic PAC fellow eyes, affected eyes had significantly shallower ACD (1.90 ± 0.23 mm vs. 1.80 ± 0.24 mm, P=0.038), and larger CLR (1.01 ± 0.23 mm vs. 1.10 ± 0.27 mm, P=0.043); but no significant difference was found in AL and LT between symptomatic PAC affected and fellow eyes.
Conclusion: PAC has thicker lens and more anterior located lens than normal controls. Symptomatic PAC-affected eyes have shallowest ACD, thicker LT and more anterior lens position, and these differences may be contributory to APAC episode.