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Haematuria: is the forgotten AKI and CKD progression factor?

Manal Abdelsalam

Hematuria is a common urinary finding present in several glomerular diseases and patients withbad control of coagulation, among other conditions. Classically, haematuria has been considered to be a benign condition associated with glomerular diseases. However, recent data from clinical and experimental studies suggest a negative role of glomerular haematuria on kidney disease progression. 
The renal damage mediated by hematuria is related to nephrotoxic actions of Hb and heme on tubular cells, although data from some  studies may suggest that the podocyte may be another cellular target of these molecules. Inflammation and oxidative stress are key processes involved in hematuria-related diseases, and may be plausible targets to develop novel therapeutic approaches