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Genetic Polymorphism of Nerve Injury-induced Protein 1 in Prostate Cancer

Jae Young Joung, Sang Jin Lee, Aesun Shin, Weon Seo Park, Jeong Eun Kim, Ho Kyung Seo, Jinsoo Chung, Jung-Ah Hwang, Seung-Hyun Hong, Jeongseon Kim, Kang Hyun Lee, Yeon-Su Lee*

Objective: To investigate the association of genetic variants of nerve injury-induced protein 1 (NINJ1) with risk of prostate cancer in Korean men, we performed this association study using single nucleotide polymorphism (SNP).

Materials and methods: We enrolled 383 patients with prostate cancer and 373 healthy controls. Twentysix candidate SNPs of the NINJ1 gene were selected for genotype analysis. The distribution of each genotype and haplotype was analyzed, and their association with the incidence of prostate cancer was evaluated.

Results: None of the SNPs and haplotypes showed significant associations with prostate cancer risk in our subjects. In relation to the genotype frequency, 14 out of the 24 characterized SNPs revealed monomorphic features in cases and controls.

Conclusions: Although no association was observed between SNPs of the NINJ1 gene and prostate cancer risk, this study is meaningful because it is the first report to investigate the genetic epidemiology of the NINJ1 gene in relation to the development of prostate cancer. In addition, we observed monomorphic features of several SNPs of the NINJ1 gene in Korean men, and this finding was similar to that observed in Chinese and Japanese men based on the review of SNP database.