Journal de toxicologie clinique
Libre accès
ISSN: 2161-0495
ISSN: 2161-0495
Omolade A Oladele*, Helen O Nottidge, Oluwaseun O Esan, Adetolase A Bakre
Intoxication as well as infectious and metabolic diseases resulting in liver and kidney damage is the major causes of losses in poultry species. While there are no specific drugs for reversal of pathophysiology of these organs, certain herbs such as garlic have been shown to improve livability of livestock and poultry. Its probable potential at enhancing the functionality of these organs in the face of injuries/insults by intoxication was investigated. Harco cockerels subgroup supplemented with 0.25% garlic-meal and administered a single dose of 300 mg/kg acetaminophen orally at 8 week-old (G1; n=25) and subgroup without acetaminophen (G2; n=25), those not supplemented and without acetaminophen (NG2; n=25) and those not initially supplemented but administered acetaminophen and later supplemented (NG1g; n=20) had higher Newcastle disease vaccinal antibody titers (8.0 ± 0.25, 7.5 ± 0.24, 7.6 ± 0.23, 8.14 ± 0.31, respectively) in comparison with subgroup without supplementation and administered acetaminophen (NGI; n=25, 7.13 ± 0.38). Serum protein levels had a similar pattern. AST levels (U/L) were significantly higher (p<0.05) in acetaminophen subgroups G1 (79.4 ± 5.79) and NG1 (83.7 ± 7.5) than their respective controls G2 (75.1 ± 7.85) and NG2 (65.2 ± 6.84) with no corresponding increase in CK levels. At 2, 7 and 14 days post-administration of acetaminophen (PAA), creatinine (mg/dl) was significantly higher in G1 (1.44 ± 0.01, 1.42 ± 0.01, 1.44 ± 0.02) and NG1 (1.47 ± 0.01, 1.51 ± 0.01, 1.47 ± 0.01) than in G2 (1.16 ± 0.05, 1.23 ± 0.01, 1.26 ± 0.06) and NG2 (1.31 ± 0.06, 1.29 ± 0.02, 1.31 ± 0.05). Similar pattern was observed at 21 days PAA. Clinicopathological observations associated with toxic dose of acetaminophen in liver and kidneys were reversed (NG1g). Thus, exhibiting the potential of garlic in protection against hepatorenal damage or injury.