Journal de pharmacie appliquée
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Abstrait

Fabrication and In vitro Characterization of Carrageenan-Based Hydrogel for Drug Delivery Application

Ibrar Ahmed, Rizwan Ahmed*

Controlled drug delivery system is formulated for drug delivery at predetermined rate. Disruption and any type of failure in this system may be toxic and life threatening for patients. The aim of present study was to develop controlled drug delivery system by using anti-hyperglycemic drug Acarbose. Acarbose release in intestine where it produces anti-hyperglycaemic effect by delaying the absorption of glucose rather than conventional dosage forms. The main objective of present study was to fabricate cross-linked polymeric system of Genugel Gum/Polyvinyl Pyrollidone co-poly acrylic acid hydrogels by free radical polymerization method and in vitro characterization for controlled delivery. Hydrogels were fabricated by free radical polymerization technique. Hydrogels were fabricated by using Genugel gum (GG) and polyvinyl pyrollidone (PVP) as a polymer, acrylic acid (AA) as a monomer and Methylene Bisacrylamide (MBA) as across linker. To initiate the free radical polymerization ammonium peroxodisulphate/ sodium hydrogen sulphite are used. Genugel gum and PVP based hydrogels were prepared with different ratios of cross linker and monomer. For structural analysis and characterization of fabricated polymeric system FTIR, TGA, SEM and DSC were performed. PH responsive behavior was investigated by in vitro release of drug and swelling study at both basic pH (7.4) & acidic pH (1.2). TGA and DSC confirm that fabricated hydrogels are thermodynamically stable. Interactions between monomer and polymer were revealed by FTIR analysis. By increasing concentrations of polymers, monomer and cross linker gel fraction was enhanced. Swelling studies showed that swelling behaviour was more at basic pH 7.4 as compare to pH 1.2 (acidic) which confirms that hydrogels give response to pH. GG/PVP co-poly acrylic acid-based hydrogel found to be potential candidate for controlled delivery of Acarbose for supportive treatment of diabetes.

Keywords: Hydogel; Biosensors; Polymer; Genugel gum