Journal de recherche clinique et expérimentale en dermatologie
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Expression of Long Non-coding RNA in Psoriasis

Abd-El Aziz El-Rifaie, Rehab Mohamed Naguib, Laila Ahmed Rashed and Esraa Mohamed Rasheed

Background: Psoriasis is a chronic hyper proliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Long non coding RNA (lncRNAs) act as a key regulator for the inflammatory gene expression by collaborating with the transcription factors. Aim: Detection of the expression of long non coding RNA in psoriatic skin of diseased patients as compared to normal control persons to investigate the possible role of long non coding RNA in the psoriasis pathogenesis Subjects and methods: The present study included 30 psoriatic patients and 30 age, gender-matched healthy controls. 4 mm punch skin biopsy was taken from patients (psoriatic lesion) & control and it was kept in lysis solution for the stability of the studied parameters and was kept frozen at -80°C till analysis of long non coding RNA by qRT PCR. Results: The tissue level of Long Non Coding RNA values was significantly higher among patients with psoriasis as compared with normal control. Conclusion: Long Non Coding RNAs (lncRNAs) could contribute to psoriasis pathogenesis through its immunomodulatory role.