Journal de recherche clinique et expérimentale en dermatologie
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Expression of Estrogen Receptor Beta in Striae Distensae of Different Sites of the Body

Aliaa Atef and Rania Moustafa

Background: Striae distensae (Stretch marks) are common cutaneous lesions that are characterised terminally by linear bands of atrophic skin. They run perpendicular to the direction of skin tension. The pathogenesis of striae remains unclear. The etiological mechanisms involved in striae are usually classified under the headings of genetic predisposition and the mechanical rupture of dermal components as an important initiating event. The estrogen and its receptors can play an important role in the pathogenesis of stretch marks despite their presence in the epidermis.

Patients and Methods: This study was carried out on 44 female patients complaining of stretch marks on different body parts. Punch skin biopsies were taken from striae distensae of the abdomen, thighs, breasts and buttocks. Immunohistochemical staining of these samples was done using estrogen receptor beta (ER-β).

Results: The intensity of ER-β expression was significantly related with the site of the stretch marks (P=0.0124). The abdominal striae showed stronger staining and the buttocks showed the least expression of ER-β. Conclusion: Using hormonal replacement therapy on the skin showing early stretch marks can be helpful as prophylactic and therapeutic modality for stretch marks.