Journal de recherche clinique et expérimentale en dermatologie
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Evaluation of Soluble P-selectin and Leptin Serum Levels in Sera of Patients of Psoriasis and their Possible Role in the Increase in the Cardiovascular Risks in Psoriatic Patients

Naglaa Fathy Agamia and Salwa Hamdy Gomaa

Background: Psoriasis is a chronic immune mediated disease that is considered to be a multisystem disease that extends beyond the limits of the skin to affect other tissues and organs, possibly associated with enhanced atherosclerosis and risk of coronary artery disease.

Objective: The aim of this work is to evaluate the serum level of soluble p-selectin and leptin serum levels in patients with psoriasis and their possible relation to the cardiovascular risk factors in those patients also the relation between their levels and the clinical severity of the disease

Patients and methods: This study was carried on seventy patients with chronic moderate to severe psoriasis. forty of them (group A) were excluded from disorders affecting platelet activity, and compared to 20 healthy age and sex matched control subjects (control A), both groups were studied for serum soluble P-selectin level, The other thirty patients (group B) were excluded from disorders affecting serum leptin level, and compared to thirty healthy age and sex matched control subjects (control B) both groups were studied for serum leptin level.

Results: soluble P-selectin level is significantly increased in psoriatic patients in the group A in comparison to control A subjects, and there was a significant increase in serum leptin level psoriatic patients in the group B in comparison to the control B subjects. Serum leptin and soluble P-selectin levels showed a positive correlation with Psoriasis Area and Severity Index.

Conclusion: Soluble p-selectin is a marker of platelet activation and has an impact on psoriasis activity; also it can be used as a marker of psoriasis severity. Leptin is an adipose tissue derived hormone that was suggested to have a role in pathogenesis of psoriasis whether through its inflammatory role or through its permissive effect on the development of psoriasis associated metabolic risk factors.