Journal d'immunologie clinique et cellulaire
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Emerging Roles of ADAP, SKAP55, and SKAP-HOM for Integrin and NF-κB Signaling in T cells

Amelie Witte, Janine Degen, Kathleen Baumgart, Natalie Waldt, Benno Kuropka, Christian Freund, Burkhart Schraven and Stefanie Kliche

Adapter proteins are scaffolding proteins that lack enzymatic or transcriptional activity. They play a crucial role in the organization of signalosomes, which are molecular complexes involved in signal transduction. Here, we review some of the recent findings regarding the three cytosolic adapter proteins ADAP, SKAP55, and SKAP-HOM with respect to their role in T-cell adhesion, migration and proliferation.