Cardiologie clinique et expérimentale
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Abstrait

Effects of the Maternal Hypertension in Renal Development in Offspring of Rats

Sonia Regina Jurado

Background: As nephrogenesis takes place entirely before term birth and many factors may have an impact on kidney development and reduce nephron numbers. The objective of the study was to analyze the effect of hypertension during pregnancy on glomeruli and microvasculature of the kidneys in fetal and neonates.

Methods: Total nine sub-groups allocated from 3 main groups of fetuses (20th d) and newborns (2nd and 15th d) offspring’s from normotensive mothers (C), SHR and L-NAME were performed. Glomerular area and the number of glomeruli per area were determined per animal in 25 random fields of the right kidney. Also, it has assessed the thickness of tunica media of renal microvessels.

Results: Nephrons number was lower in L-NAME (2.18 ± 0.82; 2.18 ± 0.73) group compared to C (2.51 ± 0.83; 2.71 ± 0.79) at 2nd and 15th d, respectively. Glomerular area in hypertensives (L-NAME: 1.80 ± 0.46; 1.91 ± 0.44 and SHR: 1.70 ± 0.47; 1.53 ± 0.42 at 2nd and 15th d, respectively) were smaller than C (1.83 ± 0.62 and 2.17 ± 0.61, at 2nd and 15th d, respectively). Thickening of the media of arterioles was found in hypertensive animals at 2nd and 15th d compared to C.

Conclusion: Maternal hypertension causes impaired renal development which potentially may lead to hypertension in later life.