Journal de toxicologie clinique
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Effect of Thiacloprid on Reproductive Hormones and Histopathology of Reproductive Organs of Rabbit (Oryctolagus cuniculus)

Atika Islam

The present study aimed at evaluating the effect of thiacloprid on reproductive hormones and histopathology of testes and ovaries of rabbit Oryctolagus cuniculus. For this purpose, 72 rabbits, both male and female rabbits were distributed in 4 groups having equal sex ratio (1:1), i.e., each group having 9 male and 9 female rabbits. Group A was kept as control group while group B, C and D were treated with 10 mg, 20 mg and 30 mg respectively for 45 days. Specimens were analyzed on 15^th, 30^th and 45^th day of study. A significant decrease (P ≤ 0.05) in serum level of hormones, e.g., testosterone, estrogen and progesterone was recorded during the study. Histopathological studies revealed tumor formation, haemorrhages, tissue damage and degeneration, formation of cyst in ovaries, while contraction of seminiferous tubules, broadening of interstitial space, decreased number of leydig cells and haemorrhage in testicular tissues. It was concluded that thiacloprid is toxic to reproductive organs and cause damage in ovarian and testicular tissues. It is recommended that application of thiacloprid must be limited in order to prevent damage to non-target species.