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Diagnostic Accuracy and Predictive Value of Latex Agglutination Test, Rapid Cassette Test Compared to ELISA in Diagnosis of Toxoplasma gondii in Pregnant Sudanese Women

Wahaj MM, Abdalla HS, Satti AB and Kabbashi AS

Background: There are different procedures for the diagnosis of the pregnant female suspected with toxoplasmosis, however time, cost, and accuracy of the test should meat patients need.

Material and Method: Three hundered pregnant female collected from Saad Abualila hospital antenatal care unit, were undergo three different procedures for the diagnosis of Toxoplasma gondii infection. Toxolatex. Toxo IgG-IgM rapid test and ELISA were done for all pregnant female. The result described as frequency and percentage of positivity, also specificity and sensitivity of Toxolatex. Toxo IgG-IgM rapid test were assessed according to ELISA results.

Results: The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy for Latex agglutination test to detect T. gondii antibodies were: 44.6%, 71.9%, 30.5%, 82.4% and 66. %, while the specificity, sensitivity, PPV, NPV and diagnostic accuracy for rapid cassette test to detect T. gondii antibodies were: 29.2%, 88.5%, 41.3%, 81.8% and 75.67%, respectively.

Conclusion: Toxo IgG-IgM rapid test(casset) considered as good test for diagnosis of toxoplasmosis and mor specific than Toxolatex with also high diagnostic accuracy.