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Depression in Children with Systemic Lupus Erythematosus in Correlation with Disease Activity

Mervat Haroun, Heba Taher Osman*, Sara Hashem Halim, Mai Abdel Samie

Systemic Lupus Erythematosus (SLE) is a chronic, multisystem, autoimmune disease characterized by periods of increased disease activity caused by inflammation of blood vessels and connective tissue. Pediatric patients with SLE have a more severe clinical course in comparison with their adult counterparts. Compared with adults, children with SLE have more widespread organ involvement. Approximately 20% of all patients who have SLE are diagnosed in childhood. The onset of SLE is rare in those younger than 5 years of age; most pediatric patients are diagnosed in adolescence.