Journal de recherche clinique et expérimentale en dermatologie
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Cytokines Induced Skin Adverse Reactions

Jun Zhang, Ling-He Meng, Li-Tao Zhang and Guang-Xin Yu

Cutaneous adverse reaction is a common complication in association with the administration of cytokine products. Local inflammation reactions at the injection sites, widespread eruptions, exacerbation the primary autoimmune disorders and flu-like symptoms are frequently reported, besides, various rare side effects also have been observed. Though the exact mechanism is not clearly understood, the biological activities of cytokines in immunological reactions and impurities in biological products have been discussed.