The Corona Virus Disease 2019 (COVID-19) pandemic began in 2019; however, its repercussions continue to plague humans in 2023 with its short-term and long-term complications and new variants. One of the complications of the disease is its effect on human reproductive tissues, the treatment of which is crucial for the reproduction of future generations. This review explored the relationship between male and female reproductive tissue dysfunction and Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) using genetic data analysis and sequence alignment of COVID-19 patients. The alignment of a specific sequence in the virus variants and five human genes directly involved in gametogenesis, oogenesis, and fertility is interesting. The coronavirus can directly or indirectly interfere with the function of the identified genes.