Anatomie et physiologie : recherches en cours
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Comparison the effects of three forms of ketogenic diet on diabetic albino rats

Ahmed El-Sayed Nour El-Deen

Ketogenic diet are being highly effective line of treatment for metabolic syndrome and DM. This study aimed to compare the effect of three different forms of KD on diabetic rats. Fifty adult male albino rats grouped into five equal groups control groups (1) Normal (2) Diabetic control receives normal diet. Experimental (3) Diabetic receive classic Ketogenic diet (4:1). Experimental (4) Diabetic receive Ketogenic diet (3:1). Experimental (5) Diabetic receive Ketogenic diet (2:1). Fasting samples were collected at the end of the study for analysis. Biochemical analyses were done using spectrophotometric method. A significant decrease in blood glucose, serum total cholesterol, LDL, and triglycerides, serum urea and creatinine were observed while Insulin level and HDL were significantly increased. The major findings in our study is that the classic KD (4:1) is the most effective form of three main types of Ketogenic diets in this study. There was no significant difference in the histological finding between three experimental groups with minimal histological changes on pancreases, liver and kidney. These findings have clearly shown that intake of Ketogenic diet is not harmful to the liver, pancreases and kidney.