Journal des essais cliniques
Libre accès
ISSN: 2167-0870
ISSN: 2167-0870
Mohammad Mehdi Hosseini, Alireza Yousefi, Leila Ghahramani, Mohsen Rastegari and Abdoul-Rasoul Ebrahimi
Objectives: Renal colic is a type of abdominal pain usually caused by obstructive stones. The objective of this study was to compare the safety and efficacy of rectal diclofenac sodium injection (RDS) and intramuscular pethidine injection (IMP) in acute renal colic.
Materials and methods: In a prospective, double-blind, randomized, interventional clinical trial, 541 patients referred to our center with acute renal colic were divided into two groups: (1) RDS with 266 participants and (2) IMP with 275 participants. Pain relief was measured by surveying participants 10, 20, and 30 minutes after taking each medication.
Results: In the RDS group, the analgesic effects of RDS were apparent in 121 participants (45.5%) after 10 min, in 191 participants (71.9%) after 20 min, and in 233 participants (87.5%) after 30 min. 33 participants (12.5%) had no response to RDS. In the IMP group, the analgesic effects of IMP were apparent in 123 participants (44.7%) after 10 min, in 191 participants (69.5%) after 20 min, and in 254 participants (92.3%) after 30 min. 21 participants (7.7%) had no response to IMP. Statistical analysis revealed that there was no significant difference between the two study drugs for relief of renal colic pain (P = 0.06).
Conclusion: Although there is no significant difference in analgesic effect between the two drugs, the use of diclofenac sodium in suppository form is highly recommended for patients with renal colic due to its availability, lower cost, safety and self-administration.