select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='82668' and ad.lang_id='5' and j.lang_id='5' and vi.lang_id='5'
ISSN: 2155-9899
Haneen Sait, Ahmed Saleh, Waleed Alshehri, Mohammed Alsheef
Background: Antiphospholipid syndrome (APS) is an autoantibody-mediated acquired thrombophilia. It is characterized by the presence of antiphospholipid antibodies (APL) that increase the risk of thrombosis.
Objective: To compare primary versus secondary effect of APS on the development of thrombosis and its outcomes.
Design: Retrospective cohort
Setting: Thrombosis clinics at KFMC
Materials and methods: A retrospective chart review from medical and electronic records for all patients who were confirmed to have APS and attended thrombosis clinic from 2009 to 2019 at King Fahad Medical City in Riyadh Saudi Arabia. A total of 100 patients fulfilled our inclusion criteria.Variables collected include thrombotic risk factors and outcomes.
Results: A total of 100 patients were included in the final analysis. Primary APS was present in (67%) and secondary APS was present in (33%). Recurrent of DVT was associated with a 4.8-fold increase the risk of thrombosis in patients with triple positive (p=0.01). DVT progressed to PE was associated with a 3.06-fold increase risk for recurrent thrombosis in general (p=0.03). Unprovoked thrombosis was seen in most of the cases accounting for 89% showing no statistically significant differences between both groups. In pregnancy complications no major difference was observed when comparing both groups.
Conclusion: Based on our retrospective analysis of aPL database shows that thrombosis is greater in primary APS than in APS associated with SLE. However, patients with triple positive demonstrate risk factor of recurrent of DVT. Moreover, DVT progressed to PE was associated with an increased risk of thrombotic in general.