Journal d'ophtalmologie clinique et expérimentale
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Comparison of Choroidal Thickness in Acute Central Serous Chorioretinopathy and Asymptomatic Fellow Eyes in the Omani Population

Amal Al-Aliyani, Mohamed Al-Abri, Ahmed Al-Hinai, Nawal Al-Fadhil, Washoo Mal

Objective: To compare the Choroidal Thickness (CT) in eyes with acute Central Serous Chorioretinopathy (CSC) and asymptomatic fellow eyes.

Materials and methods: A prospective, observational cross-sectional and comparative clinical study was conducted in Omani patients with acute CSC. Sub-Foveal Choroidal Thickness (SFCT) was measured manually using Enhanced Depth Imaging spectral-domain Optical Coherence Tomography (EDI-OCT) both in the affected and asymptomatic fellow eyes at presentation, 6-8 weeks and 3 months.

Results: Thirty-two eyes of sixteen patients were enrolled (16 eyes with acute CSC and 16 asymptomatic fellow eyes). The majority were males (81.3%). All patients were in their third decade of life, with a mean age of 35.75 (± 2.27 SD) years (range 30-38). The mean SFCT in eyes with acute CSC at the first, second and third visits was 426.29 (± 106.36 SD), 358.55 (± 88.66 SD), 378.98 (± 83.48) μm respectively. The mean SFCT of asymptomatic fellow eyes at the first, second and third visits was 374.08 (± 99.92 SD), 351.19 (± 93.54 SD) and 351.08 (± 55.00 SD) μm, respectively. There was no statistically significant difference in the SFCT between the first and third visit in both affected and non-affected eye groups with p-values of 0.217 and 0.073, respectively. There was no statistically significant difference between the asymptomatic fellow eyes and the affected eyes in the SFCT (P>0.05) in all visits. However, there was a trend of thicker choroid in affected eyes with around 52.21 μm differences between both eyes at the first visit.

Conclusion: This study revealed the trend of increased sub-foveal choroidal thickness at least in the initial phase of acute CSC and asymptomatic fellow eyes (affected eye>asymptomatic eye). These results support the hypothesis that CSC is a bilateral condition with an initial unilateral clinical presentation associated with a thick choroid.