Journal de toxicologie clinique
Libre accès
ISSN: 2161-0495
ISSN: 2161-0495
Friday E. Uboh, Saviour U. Ufot and Eyong U. Eyong
Exposure to gasoline and diesel has been reported to induce nephrotoxicity in rats. This study was designed to assess the effect of withdrawal from exposure on the nephrotoxic effects associated with oral exposure to gasoline and diesel in male rats. Four groups of the experimental test rats were respectively exposed orally to diesel and gasoline solvents (4.0 mg/kg/day, 6 days/week) for 60 days, after which two respective groups were sacrificed for nephrotoxicity assay while the remaining two groups were withdrawn from exposure for the next 60 days before sacrificing them for biochemical assay. The results showed that oral exposure to diesel and gasoline induced a significant (p<0.05) increase in serum creatinine, urea, blood urea nitrogen (BUN) and kidney tissue malondialdehyde (MDA), as well as decrease in kidney tissue reduced glutathione (GSH) concentrations in rats. However, the percentage increase in serum creatinine, urea, BUN, kidney tissue MDA, and decrease in kidney tissue GSH concentrations recorded for rats exposed to diesel (300.1 ± 30.8, 130.3 ± 18.5, 125.6 ± 16.4, 141.8 ± 10.4 and 75.0 ± 8.6 percents, respectively) were significantly higher (p<0.05) compared to the percentages recorded for rats exposed to gasoline (150.0 ± 17.5, 80.3 ± 13.2, 72.1 ± 11.4, 120.9 ± 15.2 and 61.5 ± 10.1 percents, respectively). The result of this study also showed that withdrawal from exposure reverses the levels of serum creatinine, urea, BUN, and kidney tissue MDA and GSH to the levels approximately within the control range. This study confirms that oral exposure to diesel and gasoline may be a risk factor for nephrotoxicity, with diesel being more nephrotoxic than gasoline, and that withdrawal from exposure for equal duration of the exposure period is capable of reversing the induced nephrotoxicity in rats.