Feng Cao, Ru He, Yan Huang, Zi Li, Xiaoheng Wu, Ronglin Chen, Meixia Wang
Many trauma patients die with secondary injury by immune dysregulation where lymphocytes play an important role in immune response. This was a retrospective cohort study of adult severe trauma patients. The patient’s lymphocytes were collected in 0-3(A), 6-12(B), 24-48(C), and 49-72(D) hours after trauma. The degree of secondary injury was determined according to laboratory and clinical records. Lymphocytes play crucial role in immune response, by attacking foreign substances, such as bacteria, viruses, and other pathogens, to help protect the body from infections and diseases. In case of cardiovascular system, lymphocytes can have both beneficial and detrimental effects. Blood lymphocytes, particularly T cells and B cells, can impact the cardiovascular system through their involvement in inflammation, immune responses, and autoimmune diseases. While their actions can contribute to the development and progression of cardiovascular conditions, they also have important regulatory functions that help maintain cardiovascular health. The correlation between lymphocytes and secondary injury was analyzed, in this study. The lymphocytes in 71.2% of A group patients increased higher than the upper limit of normal range. On the contrary, the lymphocytes were less than the low limit of normal range in 62% of the other groups. The lymphocytes ratio of group B,C,D by that group A were calculated, the medians were 0.21-0.22. A significantly correlation between lymphocytes ratio and severe degree of secondary injury in the trauma patients (P=0.000), the lymphocyte counts ratio can be predicting degree of secondary injury of trauma patients. Lymphocytes significantly increased in the severe trauma patients within 3 hours, then decreased significantly in 6 to 72 hours after trauma. By calculating lymphocytes ratio in early time after trauma can be used to predict the degree of secondary injury, and there was better sensitivity and specificity.