Cardiologie clinique et expérimentale
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Cardio-Protective Effects of Oxygen: New Applications of an Old Therapeutic Tool

Asghar Mohamadi*, Bahram Rasoulian

Myocardial infarction is one of the major causes of mortality in western countries imposing huge annual costs. Ischemia-reperfusion injury in myocardial infarction is one of the major damages occurring during thrombolytic therapy which increases infarct size. In this regard,introduction of treatment strategies capable of reducing the infarction-induced damages could play an important role in reducing the mortality rate. Pre-conditioning phenomenon is one of the defence mechanisms which can reduce ischemic reperfusion injury resulting in reduction of infarct size and fatal ventricular arrhythmias. Oxygen pre-treatment either in normobaric or hyperbaric conditions are among the strategies capable to induce cardio protection in various models. Reactive oxygen species are involved in the mechanism of this protective phenomenon. In this review article, both animal and human studies in this field are discussed.