Immunothérapie : Libre accès
Libre accès

Abstrait

Budesonide Suppresses Pulmonary Antibacterial Host Defense by Down-Regulating Cathelicidin-Related Antimicrobial Peptide

Xi Dai and Guoping Li

Some previous evidences have proven that Inhaled Corticosteroids (ICS) increased a risk factor for pneumonia in asthma. However, it remains unclear that ICS impacts the antibacterial host defence of lung in asthma. We aim to explore the direct impact of glucocorticoids on host defence against bacterial during asthma. We examined the effect of budesonide in host defence against P. aeruginosa and Cathelicidin-Related Antimicrobial Peptide (CRAMP) in HDM-challenged mice and lung epithelial cell lines. We found that inhaled budesonide increased P. aeruginosainduced lung inflammation in OVA-challenged mice. Inhaled budesonide reduced the production of CRAMP in lung in OVA-challenged mice. Total bacterial CFUs were significantly higher in MLE-12 cells exposed to budesonide. The effect of budesonide on bacterial CFUs in MLE-12 cells was dose-dependent. Collectively, these findings demonstrated that inhaled budesonide suppressed pulmonary antibacterial host defence depending on the downregulation of CRAMP in asthma.