Anesthésie et recherche clinique
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Brain Protection Effect of Lidocaine Measured By Interleukin-6 and Phospholipase A2 Concentration in Epidural Haematoma with Moderate Head Injury Patient

Diana Ch Lalenoh, Tatang Bisri and Irawan Yusuf

The aim of this study is to find out the neuroprotective mechanism of lidocaine in epidural haematoma (EDH) in moderate brain injury. The effects are measured by the level of interleukin-6 (IL-6) and phospholipase A2 (PLA2). This study is done in forty epidural haematoma patients with moderate brain injury. The objects are divided into two groups, group A with NaCl 0.9% infusion only (control) and group B with NaCl 0.9% infusion combined with lidocaine 1 mg/kg/hr. The blood samples were taken right before induction and two hours after infusion.

The result shows that the level of IL-6 and PLA2 is significantly low in group B (p<0.005) with Mann Whitney and Dependent t test. The decreasing level of IL-6 and PLA2 is related with the dose of lidocaine. The inhibition mechanism of IL-6 and PLA2 secretion by lidocaine is considered as a responsible factor in inflammation and brain cells damage.

Summary

• Infusion of lidocaine 1 mg/kg/hr will decrease the level of IL-6 in moderate brain injury

• Infusion of lidocaine 1 mg/kg/hr will decrease the level of PLA2 in moderate brain injury