select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='51706' and ad.lang_id='5' and j.lang_id='5' and vi.lang_id='5' Bitter Components in Beer Regulate Microglial Inflammation a | 51706
Journal d'immunologie clinique et cellulaire

Journal d'immunologie clinique et cellulaire
Libre accès

ISSN: 2155-9899

Abstrait

Bitter Components in Beer Regulate Microglial Inflammation and Prevent Cognitive Decline

Yasuhisa Ano, Akihiko Takashima and Hiroyuki Nakayama

Epidemiological studies suggest that moderate consumption of alcoholic beverages can reduce the risk of dementia . Recent work has demonstrated that intake of iso-α-acids, the bitter components in beer; prevent Alzheimer’s disease pathology by regulating microglial function. In a transgenic mouse model of Alzheimer’s disease, iso-α-acid intake led to a significant reduction of Aβ and inflammatory cytokines. In addition, iso-α-acids enhanced microglial phagocytosis of Aβ and induced microglia to an anti-inflammatory M2 type. These findings suggest that iso-α-acid consumption in daily life may be beneficial in preventing dementia.

Clause de non-responsabilité: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été révisé ou vérifié.
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