Journal d'ophtalmologie clinique et expérimentale
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Bilateral Lacrimal Gland Mantle Cell Lymphoma: A Case Report and Review of the Literature

Cristiana Bellan, Polito Maria Sole, Barbarino Marcella, Polito Ennio, Kenneth O Simbiri, and Antonio Giordano

Background: In this report we will describe a case of mantle cell lymphoma (MCL) in the conjunctiva and underlying clinical, histologic, immunological and genetic findings jointly with review of current literature.
Case presentation: Here we report a case of MCL presenting as bilateral conjunctival masses of a period of over four in a 70-year-old man.
Method and results: Histological examination revealed a proliferation of monotonous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. The lymphoid infiltrate expressed CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11.
Conclusion: We suggest a more focused approach to differential diagnosis of this cancer, as MCL is a more aggressive disease than other entities. Due to the rarity of this lymphoma a multidisciplinary team is essential to achieve the best therapeutic approach.