Pédiatrie clinique : libre accès
Libre accès

Abstrait

Application of Nutritional Support Therapy in Ataxia-Telangiectasia: A Narrative Review

Yayu He, Chenhan Luo, Yiru Wang, Ying Zhang, Donglan Wang, Canyang Wang, Zehui He, Xueqiong Yao

Ataxia-Telangiectasia (A-T) patients are vulnerable to malnutrition and growth failure, mainly due to recurrent infections, feeding disorders, choking and other swallowing difficulties. As a result, the nutritional intake of A-T patients is insufficient, which affects the development of the disease as well as the prognosis and the quality of life. Previous studies have demonstrated that early and appropriate nutritional support can relieve malnutrition, enhance immunity, improve neurological function as well as reduce the risk of infectious complications. Therefore, optimal nutritional support should be considered as an important part of the treatment of A-T. In this review, we discuss the main nutritional intervention methods for patients with A-T, including micronutrient supplementation, dietary supplement intake, diet management, enteral nutrition, nutritional monitoring, assessment and nutritional education. We emphasize the critical role of nutritional supportive therapy in the treatment of A-T for functional improvement, better prognosis and life quality. Aiming to provide new therapeutic ideas for A-T patients who are currently without effective treatment.