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Anti-hyperglycemic and Anti-hyperlipemia Effects of Syzygium Cumini Seed in Alloxan Induced Diabetes mellitus in Swiss Albino Mice (Mus musculus)

Mohd. Sufiyan Siddiqui, Bhaskar Sharma and Gurudayal Ram

Context: Syzygium cumini commonly known as jamun, a tree grown throughout India is used in traditional
medication for the treatment of different diseases and ailments of human beings.
Objective: In this study, the seed extract of Syzygium cumini was evaluated for anti-hyperlipidemic activity
in alloxan induced diabetic mice.
Materials and methods: LD50 and acute toxicity studies of Syzygium cumini (SC) were done. Hyperglycemia was induced in mice by alloxan. Three days after alloxan induction, the hyperglycemic mice were treated with Syzygium cumini orally at the dose of 150 and 250 mg/kg body weight daily for 21 days. After 21days of treatment, the animals were sacrificed and serum glucose and lipid profiles were estimated in the serum.
Results: The LD50 was found to be 1000 mg/kg; 150 and 250 mg/kg doses were selected as no toxic
symptoms were observed at both doses. SC significant (p<0.05) reduced serum glucose level, CH, TG-C, LDL-C, VLDL-C and increased HDL-C, body weight and liver, kidney weight.
Conclusion: The above results prove potential of hypoglycemic and anti-hyperlipidemic activity Syzygium
cumini.