Journal du métabolisme des médicaments et de la toxicologie
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Acute Mixed Hepatitis Induced by Propylthiouracyl. Case Report

Hakkı Yılmaz and Mustafa Kaya

29-year-old woman with Graves’ disease oral propylthiouracil, 200 mg per day. After 18 days she presented mixed type hepatitis. Ä°n this case, propylthiouracil induced a mixed pattern of cytotoxic and cholestatic hepatitis. Up to now, in english literature only one case report (Propylthiouracil-induced only cholestatic jaundice). But this case is cholestatic hepatitis. According to our knowledge, there was no published mixed type hepatitis of PTU. To our knowledge, this is the first case in the litterature.
Early recognition of PTU-induced hepatic failure and prompt withdrawal of the drug may prevent progression from mild to severe disease, it may be prudent to discuss signs and symptoms of liver disease and other side effects with patients. Jaundice, pruritus, dark urine, abdominal pain, anorexia, or malaise should signal a patient to seek medical attention.