Journal des essais cliniques

Journal des essais cliniques
Libre accès

ISSN: 2167-0870


Activation of Nasal Mucociliary Clearance by Orange Essential Oil

Ikumi Takada, Hiroaki Miyoshi, Takuya Mori*, Noriyasu Ota

Purpose: The main purpose of the present study was to identify a volatile material that activates human Nasal Mucociliary Clearance (NMC).

Methods: Ten volatile materials were evaluated in human nasal epithelial cells (MucilAir) by measuring Ciliary Beat Frequency (CBF). The effect of orange essential oil on the chloride channel was assessed in the human intestinal epithelial cell line, T84, using the fluorescent dye N-(ethoxycarbonylmethyl)-6-methocyquinolinium bromide (MQAE) corresponding to intracellular chloride. A total of 13 individuals participated in the study, and the effect of orange essential oil on human NMC was measured using saccharine test.

Results: Treatment of spearmint Midwest rectified bergamot oil Italy bergapten free and orange essential oil significantly increased CBF in MucilAir compared with treatment of mineral oil (the control). In addition, it was observed that orange essential oil activated the chloride channel in T84 cells using MQAE. Finally, the median NMC time periods of the saccharine test were 1,000 s in the control group and 850 s in the orange essential oil group (p<0.05), indicating that inhalation of orange essential oil improves NMC in humans.

Conclusion: Our results indicated that inhalation of orange essential oil improved NMC. In addition, some volatile materials might serve to improve NMC to protect from pathogen.