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Acetylcholinesterase Inhibitory Effect and Characterization of the Essential Oil of Plectranthus aegyptiacus (Forssk.) C. Chr. Growing in Nigeria

Christianah Abimbola Elusiyan, Idowu Olawuni, Tiwalade Adewale Olugbade, Omolara Orafidiya and Armando McDonald

Essential oil of fresh leaves of Plectranthus aegyptiacus (Forssk.) C. Chr. collected in Nigeria was analyzed to determine its chemotype. A total of 30 compounds were identified. Constituents identified were mainly mono and sesquiterpenoids with the major components, accounting for about 76% of the components, being α-terpinene (6.9%), p-cymene (14.2%), γ-terpinene (5.5%), carvacrol (10.0%), α-copaene (5.3%), α-caryophyllene (5.8%), germacrene-D (11.6%), δ-cadinene (8.4%) and α-cadinol (8.4%). The essential oil showed anticholinesterase inhibitory activity with an IC50 of 8.29 ± 0.67 mg/ml.