Journal de la nanomédecine et de la découverte biothérapeutique
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A New Cyanoacrylate Colloidal Polymer with Novel Antibacterial Mechanism and Its Application to Infection Control

Shoichi Shirotake

The cyanoacrylate polymer particles, which do not contain antibiotics or antibacterial agents, bond with the cell wall of drug-resistant bacteria, and then induced an auto-destructive behavior that causes the bacteria to destroy itself. Because of this, the drug-resistant bacteria are unable to arise.

One noteworthy point of this nano-polymer is that it excels in safety given its induction of bacteria auto-destruction. The raw ingredients of this polymer consist only of biodegradable acrylic adhesives used in clinical practice and saccharides; thus, there have been no observed side effects in oral administration, tail vein administration, celiac administration, or intramuscular administration in mice. In this way, there are no other antibacterial agents that are superior to our nano-polymer in terms of safety given this antibacterial mechanism.