Journal d'ophtalmologie clinique et expérimentale
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A New Approach to Ocular Surface Disease Treatment

Galina Semak, Elham Rezaei, Irina Zherka

The purpose of this study is to develop an algorithm for Chronic Corneal Dystrophic Disease treatment using 1% sodium hyaluronate in the complex treatment as well as updating drug information in the treatment of corneal dystrophy. The efficiency of eye surface disease treatment by subconjunctival injection of 1% sodium hyaluronate is studied. The study describes hyaluronic acid functions depending on its molecular weight. It shows the necessity of using sodium hyaluronate of low molecular weight (500-700 kDa) in the treatment of patients with eye surface disease after keratitis. The study includes 40 patients aged 21 to 82 years. Patients had ocular surface disease in the outcome of inflammatory diseases accompanied by dry eye disease of varying severity for 2-10 years. The result shows that injections of exogenous HA during keratopathies treatment may contribute to the regeneration and activation of metabolic processes in the tissues of the cornea.