Journal de recherche clinique et expérimentale en dermatologie
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A Double Blinded, Randomized, Controlled Split-Face Study to Investigate the Efficacy of a Tailor-made Anti-Ageing Skin Care Regimen Adapted to a Genetic Skin Ageing Risk Profile

Barbara Geusen, Liliana Rodrigues, Rita Matias, Bárbara Tavares*, Ana Luísa Fonseca, Ana Margarida Silva, Patrícia Oliveira, Marta de Oliveira Ferreira, Dea Zhilivoda, Géraldine Lagast

Background: Available data suggests that the manifestation of aging has a strong genetic basis, which can modify an individual ‘ s susceptibility to specific skin aging signs. Proteins such as matrix metalloproteinases, aquaporins, filaggrin, superoxide dismutase and glutathione peroxidase have specific roles. Their encoding genes present single nucleotide polymorphisms resulting in different responses to skin aging for elasticity, hydration, barrier function and wrinkles.
Aim: This study aimed to investigate the anti-ageing and anti-oxidant efficacy of a skin care regimen designed to address the specific needs of a certain genetic risk profile: high risk for collagen breakdown, medium risk for antioxidant production and low risk for dehydration and impaired barrier function.
Methods: DNA samples of 100 participants were collected for genetic profile analysis. Of these, 24 participants presenting the most abundant genetic risk profile were enrolled on a 56 days anti-aging efficacy study of a combined treatment. The antioxidant efficacy of one investigational product was assessed for 14 participants.
Results: Significant wrinkle’s depth and skin roughness improvements were found for the investigational treatment in comparison to the comparator and baseline. No variations were observed for the skin hydration and barrier function when compared to the comparator. The skin serum provided a significant antioxidant efficacy up to 24 h.
Conclusion: A skin care regimen designed to address the specific needs of a genetic risk profile characterized by high risk for collagen breakdown and medium risk for low anti- oxidant production was effective on decreasing wrinkles, improving skin roughness and protecting the skin from UV oxidative damage.