Anatomie et physiologie : recherches en cours
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A Case of Inflammatory Reduction with Ozone Treatment of Disc Herniation and Histological Changes

Dario Apuzzo, Paolo Ferrazza, Marchilia Piscitelli and Ergena Melengu

Objectives: Ozone therapy can stop pain caused by the intervertebral disc degeneration, associated with an extrusion of nucleus pulpous that cause inflammatory changes.

Materials and methods: Bilateral intramuscular O2O3 infiltrations, injected on the disk lesion site with a paravertebral approach. An Oxygen-Ozone mixture at a rate of 20 μg/ml was obtained by means of an Ozone generator.

Results: The loss of matrix components of nucleus pulpous herniation causes pain due to stimulation of inflammation and not caused by mechanical nerve pressure.

Conclusion: The action of oxygen-ozone is the regeneration of the annulus fibrosus of disc herniation and reduction of inflammatory chain generation. It is also confirmed by the persistence of the mechanical pressure on the nerve but the inflammatory and pain symptoms have disappeared.