Journal d'immunologie clinique et cellulaire
Libre accès

Abstrait

A Brief Note on Cell Mediated Immune Responses

Fransis Divin

Tuberculosis is essentially a lung illness, and its spread is dependent on the productive infection of this vital organ. The acquired cellular immune response to Mycobacterium tuberculosis (Mtb) infection by aerosol is extremely slow to be produced and expressed within the lung. This slowness permits infection to take hold and compels the acquired response to take place in the setting of an inflammatory location that the bacteria has started and manipulated. Mtb possesses a range of surface chemicals that interact with the innate response, and this interaction, combined with the immune response's auto-regulation by numerous mechanisms, resulting in bacterial growth control that is less than optimum. Understanding of the mechanisms that mediate the development, expression, and modulation of the immune response in the lungs is necessary for improving current vaccine tactics. We also need to figure out how to trigger both known and new immune protection responses without triggering immunological pathology.