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Tuning in Tumor Metabolism: The Cost of Being a Cancer Cell

V Krishnan Ramanujan

The genetic origin of cancers has been now accepted as a central principle of oncogenesis and the continued discovery of oncogenes and tumor suppressor genes is expanding the labyrinths of complexity in cancer biology. Molecular pathway analyses of the critical oncogenes and their aberrant genetic modificationshave given a wealth of information on the deregulation of these pathways in cancer and how this knowledge can be exploited for designing drugs for cancer treatment.