Troubles immunologiques et immunothérapie
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Targeting Immune-Evasion Mechanisms as a Possible New Approach in the Fight against Tuberculosis

Roberto Nisini

The emergence of multidrug resistant Mycobacterium tuberculosis (Mtb) strains, the difficulties in the development of new safe therapies or the production of a protective vaccine against tuberculosis make the study of the strategies developed by Mtb to escape from the host immune system an important source of potential targets of immunointervention in the fight against tuberculosis. A mechanism of immune-evasion specific for the post-primary tuberculosis based on the differentiation of disabled antigen presenting cells is described.