Système orthopédique et musculaire : recherche actuelle
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Genetics of Common Musculoskeletal Disordersin Adults

Je-Hyun Yoo, Hind Sawan and Javad Parvizi

Common musculoskeletal disorders in adults are mostly degenerative and polygenic diseases influenced by both
genetic and environmental factors.Hence, the identification of susceptibility genes may provide clues to their etiology
and pathogenesis and this genetic study is demanded to gain better insight into advanced diagnosis and treatment
for these disorders. Osteoarthritis (OA) of hip and knee joints, degenerative disc disease (DDD), and developmental
dysplasia of the hip (DDH) are common musculoskeletal disorders in adults, and numerous genetic studies including
genome-wide association studies have revealed several interesting predisposing candidate genes for these
disorders along witha genetic overlap amongthose to date. However, only a few genes have far been associated
with the above disorders at genome-wide significance levels. Accordingly, we have to discover additional
susceptibility alleles for these disorders. This brief report describes the presence and future for geneticstudies of
common musculoskeletal disorders in adults, especially focused on OA, DDH, and DDD, of which the genetics have
been actively studied through advanced technique such as whole-genome sequencing recently.