Journal de la nanomédecine et de la découverte biothérapeutique
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Design of aggregation resistant protein biotherapeutics

Salvador Ventura

Protein biotherapeuticshas emerged as promising new drugs for human disorders. However, they are extremely sensitive to stress, a major problem being the formation of aggregates during production and delivery, which impact the product quality and produce adverse immunogenic reactions. Here the author introduces A3D, an evolution of the AGGRESCAN algorithm, a new tool able to predict and assist the redesign of aggregation propensity in protein 3D-structures.