Chimie organique: recherches en cours
Libre accès

Abstrait

Criblage de modificateurs chimiques comme méthodes d'identification des composés ciblant les voies et de prédiction des interactions médicamenteuses

Naoyuki Nishiya

Screenings for genetic modifiers, such as suppressors or enhancers, in model organisms have identified and characterized important signaling pathways. Likewise, a phenotype induced by a chemical compound can be suppressed or enhanced by another compound. Here, I introduce chemical modifier screenings as phenotype-based assays that expand therapeutic targets to unexpected molecules and that facilitate identification of target signaling pathways. Also, chemical modifier screening can be applied to predicting possible drug-drug interactions that cause adverse effects.