Candido PBM, Anjos CSD, Rosa VDL, Rapatoni L, Peria FM and Fischer IR
Gastrointestinal Stromal Tumors (GIST) is the most frequent sarcoma of the gastrointestinal tract. In metastatic disease or locally advanced (inoperable) imatinib is the standard therapy, even in situations where the patient has already received adjuvant treatment with the same drug and has not presented disease progression in that period. This case report exemplifies a rare adverse effect secondary to the use of imatinib. Most of the published reports describe a greater frequency of hypopigmentation of the skin, but the patient presented bluish hyperpigmentation of the oral mucosa and over extensive areas of the skin.