Journal de toxicologie clinique
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Abstrait

Acute Liver Failure Induced by Sorafenib Combined with Diclofenac Sodium: A Case Report

Yue-Song Yin, Yu-Pei Wu, Xin-Na Deng, Li-Xiang Bai and Qing-Xia Li

Introduction: Drug-induced liver injury is one of the most common adverse drug reactions in clinical. Sorafenib is a widely used in hepatoma patients, while diclofenac sodium in patients suffering from cancer pain. Both of the two drugs showed mild and unfrequented liver damage. However, taking both drugs orally at the same time may cause severe liver function abnormity and there are few reports at present.
Case report: We'll expatiate on an unusual case of a patient with kidney cancer who takes sorafenib and diclofenac sodium simultaneously and suffered from severe and acute liver failure about nearly two months.
Conclusion: Sorafenib and diclofenac are likely to have some interactions. Clinically, the combination of the two should be carefully considered to reduce the potential risk of liver damage and avoid liver failure or even liver necrosis.