Journal des maladies infectieuses et de la médecine préventive
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A Prospective Study of Drug Induced-Skin Reactions: Patient Approaching Department of Dermatology in Secondary Care Hospital

Raju Niraula, Punnam Chandar Thoutoum, Anuja Devkota, Sangita poudel

Background: Cutanious Adverse drug reaction is any noxious change in skin which is suspected to be due to drug, occurs at doses normally used in humans for prophylaxis, diagnosis, therapy of disease or for modification of physiological function. Adverse drug reactions cause both morbidity and mortality.

Objectives: To study the clinical spectrum of cutaneous adverse drug reactions.

Methods: The study was carried out in the Department of Dermatology of Jaynagar general hospital, banglore from June 2016-July 2019. All the patients attending the Dermatology Outpatient Department and the patients admitted in the wards with suspected cutaneous adverse drug reactions to systemic drugs were included in the study. A detailed clinical history, including the history of drug intake was noted. Each case was assessed for its causality by using the WHO definitions.

Results: Patients with drug reactions were found to be more commonly female (66.28%) than male (33.72%). Antiretroviral drugs were found to be the most frequent cause of adverse cutaneous drug reactions (22.35%). Followed by non-steroidal anti-inflammatory drugs (16.86%). Acute urticaria (53.33%) was the most common clinical condition among all patients CADR followed by FDE (19.21%). most cases are seen after 24 hours to 1 week is 26.27%.

Conclusion: Adverse cutaneous drug reactions in our study population were mainly induced by anti-retroviral drugs and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fixed drug eruptions, and maculopapular rashes.